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valacyclovir hydrolase; VACVase; biphenyl hydrolase-like protein; biphenyl hydrolase-related protein; Bph-rp; breast epithelial mucin-associated antigen (MCNAA, BPHL)
Function:
1) serine hydrolase
2) catalyzes hydrolytic activation of amino acid ester prodrugs of nucleoside analogs, including valacyclovir & valganciclovir
3) activates valacyclovir to acyclovir
4) role in detoxification processes
Structure:
- monomer
- belongs to the AB hydrolase superfamily, lipase family
Alternative splicing: named isoforms=2
Expression:
- expressed in liver, kidney > heart, intestine, skeletal muscle
General
hydrolase
Properties
SIZE: MW = 33 kD
entity length = 291 aa
MOTIF: signal sequence {1-37}
serine residue {S139}
aspartate residue {D244}
histidine residue {H272}
Database Correlations
OMIM 603156
UniProt Q86WA6
Pfam PF00561
ENZYME 3.1.-.-
References
UniProt :accession Q86WA6