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urine telomerase reverse transcriptase promotor gene mutation (uTERTpm)

Indications: - detection of bladder cancer [1] * detectable years before the clinical diagnosis of bladder cancer [1] Principle: - detects mutations in the promoter of the TERT gene [1] Clinical significance: - TERT promoter mutations have been detected in 60-85% in all stages & grades of bladder cancers [1]

General

urine chemistry test DNA (genetic) testing

References

  1. Nelson R Simple Urine Test Could Improve Detection of Bladder Cancer. Medscape. May 24, 2022 https://www.medscape.com/viewarticle/974499 - International Agency for Research on Cancer (WHO) Improving Early Detection and Clinical Management of Bladder Cancer. A promising urine test (uTERTpm). https://www.iarc.who.int/wp-content/uploads/2022/05/IARC_Evidence_Summary_Brief_3.pdf