uroplakin-3a; UP3a; uroplakin 3; UP3 (UPK3A UPK3)

Function: - component of the asymmetric unit membrane (AUM) - role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells - contributes to formation of urothelial glycocalyx which may function in preventing bacterial adherence - heterodimer with uroplakin-1B (UPK1B) (putative) Structure: - belongs to the uroplakin-3 family Compartment: - endoplasmic reticulum membrane - single-pass type 1 membrane protein (putative) - heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER) (putative) Alternative splicing: named isoforms=2 Expression: - expressed in ureter Pathology: - defects in UPK3A are a cause of renal agenesis

General

glycoprotein uroplakin

Properties

SIZE: entity length = 287 aa MW = 31 kD COMPARTMENT: endoplasmic reticulum MOTIF: signal sequence {1-18} N-glycosylation site {N74} N-glycosylation site {N139} N-glycosylation site {N170} transmembrane domain {208-235}

Database Correlations

OMIM correlations UniProt O75631 Entrez Gene 7380 Kegg hsa:7380

References

UniProt :accession O75631