Search
uroplakin-1b; UP1b; uroplakin Ib; UPIb; tetraspanin-20; Tspan-20 (UPK1B TSPAN20)
Function:
- component of the asymmetric unit membrane (AUM)
- role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (putative)
- heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B) (putative)
Structure:
- N-glycosylated with high-mannose oligosaccharides
- belongs to the tetraspanin (TM4SF) family
Compartment: membrane
Expression: bladder epithelium
General
glycoprotein
transmembrane 4 protein
uroplakin
Properties
SIZE: entity length = 260 aa
MW = 30 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {2-15}
transmembrane domain {16-36}
exoplasmic loop {37-60}
transmembrane domain {61-81}
cytoplasmic loop {82-86}
transmembrane domain {87-107}
exoplasmic loop {108-229}
transmembrane domain {230-250}
cytoplasmic domain {251-260}
Database Correlations
OMIM 602380
UniProt O75841
Pfam PF00335
Entrez Gene 7348
Kegg hsa:7348
References
UniProt :accession O75841