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uroplakin-1a; UP1a; uroplakin Ia; UPIa; UPKa; tetraspanin-21; Tspan-21 (UPK1A, TSPAN21)
Function:
- component of the asymmetric unit membrane (AUM)
- role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (putative)
- interacts with uroplakin-2 (UPK2) (putative)
Structure:
- homodimer; disulfide-linked.
- belongs to the tetraspanin (TM4SF) family
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- high expression restricted to ureteric urothelium (most superficial cells)
- low expression in prostate expression in normal urothelial cells is lost in culture
- some expression in tumor cell lines derived from urothelial malignancies
General
glycoprotein
transmembrane 4 protein
uroplakin
Properties
SIZE: entity length = 258 aa
MW = 29 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-14}
transmembrane domain {15-35}
exoplasmic loop {36-59}
transmembrane domain {60-86}
cytoplasmic loop {87-91}
transmembrane domain {92-112}
exoplasmic loop {113-230}
MOTIF: N-glycosylation site {N170}
transmembrane domain {231-252}
cytoplasmic domain {253-258}
Database Correlations
OMIM 611557
UniProt O00322
Pfam PF00335
Entrez Gene 11045
Kegg hsa:11045
References
UniProt :accession O00322