uromodulin-like 1 (olfactorin, UMODL1)

Compartment: - cell membrane - isoform 3 & 4: cytoplasm Alternative splicing: - named isoforms=4 - additional isoforms seem to exist in testis Expression: - isoform 4 is expressed at low level in kidney, testis & fetal thymus - isoform 3 is expressed at low level in prostate, testis & fetal thymus Structure: - contains 3 EGF-like domains - contains 1 EMI domain - contains 2 fibronectin F3 modules - contains 2 SEA domains - contains 1 WAP domain - contains 1 ZP domain

General

glycoprotein membrane protein

Properties

SIZE: MW = 144 kD entity length = 1318 aa COMPARTMENT: cytoplasm MOTIF: signal sequence {1-21} EMI {33-106} MOTIF: cysteine residue {C37} MODIFICATION: cysteine residue {C94} cysteine residue {C61} MODIFICATION: cysteine residue {C70} cysteine residue {C70} MODIFICATION: cysteine residue {C61} N-glycosylation site {N89} cysteine residue {C93} MODIFICATION: cysteine residue {C104} cysteine residue {C94} MODIFICATION: cysteine residue {C37} cysteine residue {C104} MODIFICATION: cysteine residue {C93} N-glycosylation site {N109} WAP {117-157} N-glycosylation site {N172} EGF domain {264-313} fibronectin type III domain or F3 module {313-395} MOTIF: N-glycosylation site {N322} N-glycosylation site {N335} SEA domain {395-506} MOTIF: N-glycosylation site {N417} EGF domain {507-552} MOTIF: cysteine residue {C511} MODIFICATION: cysteine residue {C525} cysteine residue {C519} MODIFICATION: cysteine residue {C534} cysteine residue {C525} MODIFICATION: cysteine residue {C511} cysteine residue {C534} MODIFICATION: cysteine residue {C519} cysteine residue {C536} MODIFICATION: cysteine residue {C551} cysteine residue {C551} MODIFICATION: cysteine residue {C536} N-glycosylation site {N585} fibronectin type III domain or F3 module {703-787} MOTIF: N-glycosylation site {N713} SEA domain {787-890} EGF domain {897-938} MOTIF: cysteine residue {C901} MODIFICATION: cysteine residue {C914} cysteine residue {C908} MODIFICATION: cysteine residue {C923} cysteine residue {C914} MODIFICATION: cysteine residue {C901} cysteine residue {C923} MODIFICATION: cysteine residue {C908} N-glycosylation site {N984} ZP domain {992-1235} MOTIF: cysteine residue {*1} MODIFICATION: cysteine residue {*2} cysteine residue {*2} MODIFICATION: cysteine residue {*1} N-glycosylation site {N1050} transmembrane domain {1273-1293}

Database Correlations

UniProt Q5DID0 PFAM correlations

References

UniProt :accession Q5DID0