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uridine-cytidine kinase-like 1 (UCKL1, URKL1, F538)
Function:
- may contribute to UTP accumulation needed for blast transformation & proliferation
- pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
- pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1
- ubiquitinated by RNF19B; which induces proteasomal degradation
- interacts with RNF19B & EBV EBNA3
ATP + uridine = ADP + UMP
ATP + cytidine = ADP + CMP
Structure: belongs to the uridine kinase family
Compartment:
- cytoplasm, nucleus
- EBNA3 induces isoform 1 translocation to the nucleus
Alternative splicing: named isoforms=3
Expression: ubiquitous
General
kinase or ATP-phosphotransferase
Properties
SIZE: entity length = 548 aa
MW = 61 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S16}
Ser phosphorylation site {S56}
ATP-binding site
NAME: ATP-binding site
SITE: 105-112
MOTIF: Ser phosphorylation site {S107}
Ser phosphorylation site {S539}
Database Correlations
OMIM 610866
UniProt Q9NWZ5
Pfam PF00485
Entrez Gene 54963
Kegg hsa:54963
ENZYME 2.7.1.48
References
UniProt :accession Q9NWZ5