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upstream stimulatory factor 1; class B basic helix-loop-helix protein 11; bHLHb11; major late transcription factor 1 (USF1, BHLHB11, USF)
Function:
- transcription factor & DNA-binding protein
- binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3' found in a variety of viral & cellular promoters
- efficient DNA binding requires dimerization with another bHLH protein
- binds DNA as an homodimer or a heterodimer (USF1/USF2)
- interacts with varicella-zoster virus IE62 protein
Structure: contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus
Pathology:
- genetic variations in USF1 are associated with combined hyperlipidemia type 1
General
basic helix loop helix (bHLH) family transcription factor
Properties
SIZE: entity length = 310 aa
MW = 34 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 200-212
helix-loop-helix
NAME: helix-loop-helix
SITE: 213-255
FOR-BINDING-VIA: helix-loop-helix
leucine zipper
SITE: 271-292
FOR-BINDING-VIA: leucine zipper
MISC-INFO: COPIES 50000 MOLECULES/CELL
Database Correlations
OMIM correlations
MORBIDMAP 191523
UniProt P22415
Pfam PF00010
Entrez Gene 7391
Kegg hsa:7391
References
- UniProt :accession P22415
- SeattleSNPs
http://pga.gs.washington.edu/data/usf1/