Upstream-binding protein 1 (LBP-1) (UBP1 LBP1)

Function: - transcriptional activator (promoter context-dependent) - modulates placental expression of CYP11A1 - role in regulation of the alpha-globin gene in erythroid cells - activation of the alpha-globin promoter in erythroid cells occurs via synergistic interaction with TFCP2 - binds strongly to sequences around the HIV-1 initiation site & weakly over the TATA-box - represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box - interacts with TFCP2 - interacts with PIAS1 - component of a complex containing TFCP2, UBP1 & PIAS1 (putative) Structure: belongs to the grh/CP2 family, CP2 subfamily Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - expressed in adrenal tissue, JEG-3, NCI-H295A, HepG2 & HeLa cell lines Pathology: induced by HIV-1 infection of lymphocytes

Properties

SIZE: MW = 60 kD entity length = 540 aa COMPARTMENT: cell nucleus

Database Correlations

UniProt Q9NZI7 PFAM correlations

References

UniProt :accession Q9NZI7