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undifferentiated connective tissue disease
Diagnostic criteria:
- syndrome with objective abnormalities that do not meet criteria for systemic lupus erythematosus or other connective tissue disease [1]
Clinical manifestations:
- most cases are mild [1]
- may have Raynaud's phenomenon & inflammatory arthritis
- over time, may evolve into specific autoimmune disease. most commonly systemic lupus erythematosus
Laboratory:
- antinuclear antibody may be positive
Management:
- NSAIDs,
- hydroxychloroquine if NSAIDs ineffective
General
connective tissue disease; soft tissue disease
syndrome
References
- Medical Knowledge Self Assessment Program (MKSAP) 17, 18, 19.
American College of Physicians, Philadelphia 2015, 2018, 2022
- Mosca M, Tani C, Carli L, Bombardieri S.
Undifferentiated CTD: a wide spectrum of autoimmune diseases.
Best Pract Res Clin Rheumatol. 2012 Feb;26(1):73-7. Review.
PMID: 22424194