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netrin receptor UNC5B (Unc-5 homolog B, Unc-5 homolog B, UNC5B, UNC5H2, p53-regulated receptor for death & life protein 1, P53RDL1, UNQ1883/PRO4326)

Function: 1) receptor for netrin 2) involved in axon guidance 3) mediates axon repulsion of neuronal growth cones in developing nervous system 4) association with DCC (cytoplasmic domain) may trigger signaling for axonal repulsion 6) apoptosis induction when NOT associated with netrin 7) interacts with GNAI2 8) induction by p53 9) phosphorylated on cytoplasmic Tyr 10) proteolytic cleavage by caspases during apoptosis does NOT occur associated with netrin ligand 11) cleavage by caspases is required to induce apoptosis Compartment: membrane Alternative splicing: named isoforms=2 Expression: - expressed in brain > developing lung, cartilage, kidney, hematopoietic & immune tissues Pathology: - down-regulated in multiple cancers including colorectal cancer breast cancer ovarian cancer uterine cancer stomach cancer lung cancer kidney cancer

Related

netrin

General

glycoprotein phosphoprotein UNC5 homolog protein

Properties

SIZE: MW = 104 kD entity length = 945 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-26} immunoglobulin superfamily domain {48-145} MOTIF: cysteine residue {C69} MODIFICATION: cysteine residue {C128} cysteine residue {C128} MODIFICATION: cysteine residue {C69} immunoglobulin superfamily domain {147-242} MOTIF: cysteine residue {C174} MODIFICATION: cysteine residue {C225} N-glycosylation site {N222} cysteine residue {C225} MODIFICATION: cysteine residue {C174} TSP TYPE-1 1 {246-300} MOTIF: cysteine residue {C258} MODIFICATION: cysteine residue {C295} cysteine residue {C262} MODIFICATION: cysteine residue {C299} cysteine residue {C273} MODIFICATION: cysteine residue {C285} cysteine residue {C285} MODIFICATION: cysteine residue {C273} cysteine residue {C295} MODIFICATION: cysteine residue {C258} cysteine residue {C299} MODIFICATION: cysteine residue {C262} TSP TYPE-1 2 {302-354} MOTIF: N-glycosylation site {N347} transmembrane domain {378-398} proteolytic site {412-413} ZU5 {541-647} binding site SITE: 707-725 FOR-BINDING-OF: netrin receptor DCC death domain NAME: death domain SITE: 865-943

Database Correlations

OMIM 607870 UniProt Q8IZJ1 PFAM correlations Entrez Gene 219699 Kegg hsa:219699

References

  1. Leonardo et al. Nature 386:833-8 1997
  2. UniProt :accession Q8IZJ1