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ulipristal acetate (Ella)
FDA-approved Aug 2010, available only by prescription
Indications:
- emergency contraceptive (plan B)
- for use within 120 hours (5 days) after failure of standard contraception or after unprotected intercourse
- hemorrhage due to uterine fibroids [4]
Dosage:
- single tablet 30 mg
Storage:
- keep the blister in the outer carton to protect from light [5]
Adverse effects:
- headache (9%)
- nausea (9%)
- abdominal pain (7%)
- dysmenorrhea
- fatigue
- dizziness
Mechanism of action:
- progesterone agonist/antagonist that works mainly by inhibiting or delaying ovulation
Specific
morning after pill
General
monophasic oral contraceptive
progestational agent
References
- Glasier AF et al
Ulipristal acetate versus levonorgestrel for emergency
contraception: A randomised non-inferiority trial and meta-
analysis.
Lancet 2010 Feb 13; 375:555.
PMID: 20116841
- FDA NEWS RELEASE, August 13, 2010
FDA approves ella tablets for prescription emergency
contraception
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm222428.htm
- Prescriber's Letter 17(10): 2010
Ella (Ulipristal) for Emergency Contraception
Detail-Document#: 261008
(subscription needed) http://www.prescribersletter.com
- Donnez J et al.
Ulipristal acetate versus placebo for fibroid treatment before
surgery.
N Engl J Med 2012 Feb 2; 366:409.
PMID: 22296075
- Donnez J et al.
Ulipristal acetate versus leuprolide acetate for uterine
fibroids.
N Engl J Med 2012 Feb 2; 366:421.
PMID: 22296076
- Stewart EA.
Uterine fibroids and evidence-based medicine-Not an oxymoron.
N Engl J Med 2012 Feb 2; 366:471.
PMID: 22296082
- Prescriber's Letter 21(6): 2014
Oral Meds to Keep in Original Containers
Detail-Document#: 300622
(subscription needed) http://www.prescribersletter.com