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UDP-N-acetylglucosamine phosphatidylinositol transferase (GPI-GlcNAc transferase, GPI-GnT)
Function:
- catalyzes transfer of N-acetylglucosamine from UDP-N-acetyl-glucosamine to phosphatidylinositol, the first step of GPI biosynthesis
Structure:
- consists of PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY, DPM2
General
molecular complex
transferase
Properties
MOTIF: active site
SUBUNITS: phosphatidylinositol N-acetylglucosaminyltransferase subunit A
COMPARTMENT: endoplasmic reticulum
MOTIF: Ser phosphorylation site {S21}
transmembrane domain {422-442}
phosphatidylinositol N-acetylglucosaminyltransferase subunit C
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {51-71}
transmembrane domain {80-100}
transmembrane domain {154-174}
transmembrane domain {239-259}
phosphatidylinositol N-acetylglucosaminyltransferase subunit H
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S6}
phosphatidylinositol N-acetylglucosaminyltransferase subunit P
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {40-60}
transmembrane domain {80-100}
phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {278-298}
transmembrane domain {349-371}
transmembrane domain {378-400}
transmembrane domain {446-468}
transmembrane domain {475-497}
dolichyl-phosphate mannosyltransferase 2
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {10-30}
cytoplasmic domain {N-TERMINAL}
exoplasmic loop
transmembrane domain {48-68}
cytoplasmic domain {C-TERMINAL}
phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
COMPARTMENT: endoplasmic reticulum
MOTIF: cytoplasmic domain {1-3}
transmembrane domain {4-26}
exoplasmic loop {27-44}
transmembrane domain {45-65}
cytoplasmic domain {66-71}
References
UniProt :accession Q969N2
Compartment: endoplasmic reticulum
Components
dolichyl-phosphate mannosyltransferase 2 (dolichol phosphate-mannose biosynthesis regulatory protein, My026 protein, DPM2)
phosphatidylinositol N-acetylglucosaminyltransferase subunit A; GlcNAc-PI synthesis protein; phosphatidylinositol-glycan biosynthesis class A protein; PIG-A (PIGA)
phosphatidylinositol N-acetylglucosaminyltransferase subunit C; phosphatidylinositol-glycan biosynthesis class C protein; PIG-C (PIGC, GPI2)
phosphatidylinositol N-acetylglucosaminyltransferase subunit H; phosphatidylinositol-glycan biosynthesis class H protein; PIG-H (PIGH)
phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Down syndrome critical region protein 5; Down syndrome critical region protein C; phosphatidylinositol-glycan biosynthesis class P protein; PIG-P (PIGP, DCRC, DSCR5, DSCRC, NPD010)
phosphatidylinositol N-acetylglucosaminyltransferase subunit Q; N-acetylglucosamyl transferase component GPI1; phosphatidylinositol-glycan biosynthesis class Q protein; PIG-Q (PIGQ GPI1)
phosphatidylinositol N-acetylglucosaminyltransferase subunit Y (phosphatidylinositol-glycan biosynthesis class Y protein, PIG-Y, PIGY)