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UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UGD; UXS-1 (UXS1)
Function:
1) catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose
2) biosynthesis of core tetrasaccharide in glycosaminoglycans
3) glycosylation pathway
4) interacts with AKT1
UDP-D-glucuronate UDP-D-xylose + CO2
Cofactor: NAD.
Structure:
- belongs to the sugar epimerase family, UDP-glucuronic acid decarboxylase subfamily
Compartment:
- Golgi
- single-pass type 2 membrane protein (putative)
Alternative splicing: named isoforms=3
General
carboxy-lyase or decarboxylase
glycoprotein
membrane protein
Properties
SIZE: entity length = 420 aa
MW = 48 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {20-40}
cofactor-binding site [119-144]
COFACTOR-BOUND: NAD
binding site
SITE: 228-228
FOR-BINDING-OF: Substrate
cofactor-binding site [231-235]
COFACTOR-BOUND: NAD
binding site
SITE: 260-260
FOR-BINDING-OF: Substrate
cofactor-binding site [272-272]
COFACTOR-BOUND: NAD
N-glycosylation site {N316}
Database Correlations
OMIM 609749
UniProt Q8NBZ7
PFAM correlations
Entrez Gene 80146
KEGG correlations
ENZYME 4.1.1.35
References
UniProt :accession Q8NBZ7