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UDP-glucose:glycoprotein glucosyltransferase 2; UGT2; hUGT2; UDP-Glc:glycoprotein glucosyltransferase 2; UDP-glucose ceramide glucosyltransferase-like 2 (UGGT2, UGCGL2, UGT2)
Function:
1) recognizes glycoproteins with minor folding defects
2) reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum
3) reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum & refolding or degradation
Cofactor: Ca+2 or Mn+2
Structure: belongs to the glycosyltransferase 8 family
Compartment:
- endoplasmic reticulum lumen
- endoplasmic reticulum-Golgi intermediate compartment
Expression:
- expressed (at higher levels) in kidney, pancreas, heart, skeletal muscle
General
glucosyl transferase
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 1516 aa
MW = 175 kD
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: signal sequence {1-27}
N-glycosylation site {N256}
N-glycosylation site {N286}
N-glycosylation site {N920}
N-glycosylation site {N950}
Glucosyltransferase {1220-1516}
MOTIF: Tyr phosphorylation site {Y1289}
ER retention {1513-1516}
Database Correlations
OMIM 605898
UniProt Q9NYU1
PFAM correlations
Entrez Gene 55757
Kegg hsa:55757
ENZYME 2.4.1.-
References
- UniProt :accession Q9NYU1
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/