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UDP-glucose:glycoprotein glucosyltransferase 1; UGT1; hUGT1; UDP-Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1 (UGGT1, GT, UGCGL1, UGGT, UGT1, UGTR)
Function:
1) recognizes glycoproteins with minor folding defects
2) reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum
3) reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum & refolding or degradation
4) functions as monomer or heterodimer with SEP15
5) N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects
Cofactor: Ca+2 or Mn+2
Structure:
- the N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects
- belongs to the glycosyltransferase 8 family
Compartment:
- endoplasmic reticulum lumen
- endoplasmic reticulum-Golgi intermediate compartment
Expression:
- expressed in pancreas, skeletal muscle, kidney, brain > lung, heart
- induced by tunicamycin, A23187; 3-4 fold induction 10 hrs after treatment
General
glucosyl transferase
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 1555 aa
MW = 177 kD
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: signal sequence {1-42}
N-glycosylation site {N536}
Ser phosphorylation site {S738}
Tyr phosphorylation site {Y741}
Ser phosphorylation site {S748}
N-glycosylation site {N1228}
Glucosyltransferase {1244-1555}
MOTIF: ER retention {1552-1555}
Database Correlations
OMIM 605897
UniProt Q9NYU2
Pfam PF06427
Entrez Gene 56886
Kegg hsa:56886
References
- UniProt :accession Q9NYU2
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/