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UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase; GlcNAc-1-P transferase; G1PT; GPT; N-acetylglucosamine-1-phosphate transferase (DPAGT1, DPAGT2)
Function:
- catalyzes initial step in the synthesis of dolichol-pyrophosphate-oligosaccharides
- protein modification; protein glycosylation
UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol
Structure: belongs to the glycosyltransferase 4 family
Compartment:
- endoplasmic reticulum membrane
- multi-pass membrane protein
Alternative splicing: named isoforms=3
Pathology:
- defects in DPAGT1 are the cause of congenital disorder of glycosylation type 1J
Related
congenital disorder of glycosylation type 1J
dolichol phosphate
UDP N-acetylglucosamine (UDP-GlcNAc)
General
glycoprotein
phosphotransferase
transmembrane 10e protein
Properties
SIZE: entity length = 408 aa
MW = 46 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: exoplasmic domain {1-6}
transmembrane domain {7-32}
cytoplasmic loop {33-57}
transmembrane domain {58-79}
MOTIF: Dolichol recognition {67-79}
exoplasmic loop {80-94}
transmembrane domain {95-114}
cytoplasmic loop {115-125}
transmembrane domain {126-145}
exoplasmic loop {146-164}
MOTIF: N-glycosylation site {N146}
transmembrane domain {165-184}
cytoplasmic loop {185-194}
transmembrane domain {195-211}
exoplasmic loop {212-221}
transmembrane domain {222-240}
MOTIF: Dolichol recognition {222-234}
cytoplasmic loop {241-252}
transmembrane domain {253-269}
exoplasmic loop {270-274}
transmembrane domain {275-294}
cytoplasmic loop {295-378}
transmembrane domain {379-397}
exoplasmic domain {398-408}
Database Correlations
OMIM correlations
MORBIDMAP 191350
UniProt Q9H3H5
Pfam PF00953
Entrez Gene 1798
Kegg hsa:1798
ENZYME 2.7.8.15
References
- UniProt :accession Q9H3H5
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/
- Functional glycomics gateway - GTase;
Note: UDP-N-acetylglucosamine-dolichyl-phosphate N-
http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewglycoEnzyme.jsp?gbpId=gt_hum_543