UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 (beta3Gn-T8, BGnT-8, beta-1,3-N-acetylglucosaminyltransferase-8, B3GNT8, B3GALT7, BGALT15)

Function: - beta-1,3-N-acetylglucosaminyltransferase - plays a role in elongation of specific branch structures of multiantennary N-glycans - strong activity towards tetraantennary N-glycans & 2,6 triantennary glycans - forms a complex of enhanced enzymatic activity with B3GNT2 in vitro - protein modification; protein glycosylation Structure: belongs to the glycosyltransferase 31 family Compartment: Golgi membrane (putative) Expression: - highly expressed in small intestine, pancreas, spleen, bone marrow, lung, throat, & ileum, & weakly in fetal brain, cerebellum, heart, liver, tongue, breast, uteri, & testis - not detected in colon Pathology: - differentially expressed in human tumor cell lines - up-regulated in colon cancer

General

beta-1,3-N-acetylglucoaminyltransferase (B3GNT1) glycoprotein

Properties

SIZE: entity length = 397 aa MW = 43 kD MOTIF: transmembrane domain {7-23} N-glycosylation site {N57} alanine-rich region {99-102} MOTIF: alanine residue (SEVERAL) glycine-rich region {133-136} active site

Database Correlations

UniProt Q7Z7M8 Pfam PF01762

References

UniProt :accession Q7Z7M8