UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (Beta3Gn-T6, BGnT-6, Beta1,3-N-acetylglucosaminyltransferase-6, core 3 synthase, B3GNT6)

Function: - glycosylation pathway - beta-1,3-N-acetylglucosaminyltransferase - synthesizes core 3 structure of the O-glycan, an important precursor in biosynthesis of mucin-type glycoproteins - role in the synthesis of mucin-type O-glycans in digestive organs Structure: belongs to the glycosyltransferase 31 family Compartment: Golgi membrane Alternative splicing: named isoforms=2 Expression: - present in stomach & colon (at protein level) - restricted in the stomach, colon & small intestine, where core 3 structure is present Pathology: - down-regulated in gastric & colorectal carcinomas - injection into nude mice significantly suppresses lung metastasis

General

beta-1,3-N-acetylglucoaminyltransferase (B3GNT1) glycoprotein membrane protein

Properties

SIZE: MW = 43 kD entity length = 384 aa COMPARTMENT: golgi MOTIF: transmembrane domain {13-31} N-glycosylation site {N73} N-glycosylation site {N77} N-glycosylation site {N196}

Database Correlations

UniProt Q6ZMB0 Pfam PF01762

References

UniProt :accession Q6ZMB0