UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5; Beta3Gn-T5; BGnT-5; Beta1,3-N-acetylglucosaminyltransferase-5; lactotriaosylceramide synthase; Lc(3)Cer synthase; Lc3 synthase; B3GNT5

Function: - glycosylation pathway - beta-1,3-N-acetylglucosaminyltransferase - role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, including HNK-1 & Lewis X carbohydrate structures - strong activity toward lactosylceramide (LacCer) & neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in synthesis of Lc(3)Cer & nLc(5)Cer (neolactopentaosylceramide), respectively - role in regulating neolacto-series glycolipid synthesis during embryonic development Structure: belongs to the glycosyltransferase 31 family Compartment: Golgi membrane Expression: - widely expressed - highly expressed in lung, colon, placenta, testis, pituitary gland & cerebellum - weakly expressed in brain, liver, spleen, lymph node & thymus - up-regulated by stimulation with retinoic acid - down-regulated with 12-O-tetradecanoylphorbol-13-acetate

General

beta-1,3-N-acetylglucoaminyltransferase (B3GNT1) glycoprotein membrane protein

Properties

COMPARTMENT: cellular membrane MOTIF: active site

Database Correlations

UniProt Q9BYG0 Pfam PF01762

References

UniProt :accession Q9BYG0