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UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 (beta-1,3-N-acetylgalactosaminyltransferase 2, beta-3-GalNAc-T2, B3GALNT2)

Function: - beta-1,3-N-acetylgalactosaminyltransferase active in synthesizing a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- & O-glycans - has no galactose nor galactosaminyltransferase activity toward any acceptor substrate Kinetic parameters: - KM=5.4 uM for UDP-GalNAc - KM=11 mM for GlcNAc-beta-Bn Structure: - belongs to the glycosyltransferase 31 family - N-glycosylated (probable) Compartment: Golgi membrane Alternative splicing: named isoforms=2 Expression: - expressed in all tissues examined - highest levels in testis, adipose tissue, skeletal muscle & ovary

General

beta-1,3-N-acetylgalactosaminyltransferase glycoprotein membrane protein

Properties

SIZE: MW = 57 kD entity length = 500 aa COMPARTMENT: golgi MOTIF: transmembrane domain {7-23} N-glycosylation site {N116} N-glycosylation site {N174}

Database Correlations

UniProt Q8NCR0 Pfam PF01762

References

  1. UniProt :accession Q8NCR0
  2. GlycoGene database http://ggdb.muse.aist.go.jp/GGDB/index.jsp