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E3 ubiquitin-protein ligase UBR2; N-recognin-2; ubiquitin-protein ligase E3-alpha-2; ubiquitin-protein ligase E3-alpha-II (UBR2 C6orf133 KIAA0349)
Function:
1) ubiquitin ligase protein, ubiquitin conjugation, 3rd step
2) component of the N-end rule pathway
3) recognizes & binds to proteins bearing specific amino- terminal residues that are destabilizing according to the N-end rule, leading to ubiquitination & subsequent degradation
4) pancreatic homeostasis
5) interacts with UBE2B
- promotes the UBE2B-H2A interaction & ubiquitination of histone H2A by UBE2B & UBR2
6) interacts with RECQL4
Structure:
- the RING-H2 Zn+2 finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif
- belongs to the UBR1 family
- contains 1 RING-type Zn+2 finger
- contains 1 UBR-type Zn+2 finger
Compartment:
- nucleus
- associated with chromatin during meiosis
Alternative splicing: named isoforms=4
Expression:
- broadly expressed
- highest expression in skeletal muscle, kidney, pancreas, acinar cells of pancreas, fetal pancreas
General
nuclear protein
zinc finger protein
Properties
SIZE: entity length = 1755 aa
MW = 201 kD
COMPARTMENT: cell nucleus
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 97-168
EFFECTOR-BOUND: Zn+2
coiled coil {1019-1054}
RING-finger {1108-1214}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Database Correlations
OMIM 609134
UniProt Q8IWV8
PFAM correlations
Entrez Gene 23304
Kegg hsa:23304
References
UniProt :accession Q8IWV8