E3 ubiquitin-protein ligase BRE1B; BRE1-B; 95 kD retinoblastoma-associated protein; RBP95; RING finger protein 40 (RNF40, BRE1B, KIAA0661)

Function: 1) E3 ubiquitin ligase protein - ubiquitin conjugation, 3rd step 2) monoubiquitination of Lys-120 of histone H2B. H2B - specific tag for epigenetic transcriptional activation - required for histone H3 Lys-4 & Lys-79 methylation 3) forms a ubiquitin ligase complex in cooperation with E2 enzyme UBE2E1 4) histone code & gene regulation 5) transcriptional activation of Hox genes. 6) component of the RNF20/40 complex 7) interacts with RB1 Structure: homodimer Compartment: nucleus Expression: ubiquitously expressed

General

nuclear protein phosphoprotein ring finger protein E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein

Properties

SIZE: entity length = 1001 aa MW = 114 kD COMPARTMENT: cell nucleus MOTIF: coiled coil {44-91} coiled coil {189-377} coiled coil {437-525} coiled coil {627-946} MOTIF: Thr phosphorylation site {T644} RING-finger {948-987} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif

Database Correlations

OMIM 607700 UniProt O75150 Pfam PF00097

References

UniProt :accession O75150