E3 ubiquitin-protein ligase BRE1A; BRE1-A; hBRE1; RING finger protein 20 (RNF20, BRE1A)

Function: 1) E3 ubiquitin ligase protein - ubiquitin conjugation, 3rd step 2) monoubiquitination of Lys-120 of histone H2B - specific tag for epigenetic transcriptional activation - required for histone H3 Lys-4 & Lys-79 methylation 3) forms a ubiquitin ligase complex in cooperation with E2 enzyme UBE2E1 4) histone code & gene regulation 5) transcriptional activation of Hox genes 6) component of the RNF20/40 complex Structure: homodimer Compartment: nucleus

General

nuclear protein phosphoprotein ring finger protein E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein

Properties

SIZE: entity length = 975 aa MW = 114 kD COMPARTMENT: cell nucleus MOTIF: coiled coil {43-90} Ser phosphorylation site {S136} Ser phosphorylation site {S138} coiled coil {168-375} MOTIF: Tyr phosphorylation site {Y314} coiled coil {429-898} MOTIF: Ser phosphorylation site {S540} Ser phosphorylation site {S545} Ser phosphorylation site {S553} RING-finger {922-961} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif

Database Correlations

OMIM 607699 UniProt Q5VTR2 Pfam PF00097 Entrez Gene 56254 Kegg hsa:56254

References

UniProt :accession Q5VTR2