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E3 ubiquitin-protein ligase HECTD1; E3 ligase for inhibin receptor; EULIR; HECT domain-containing protein 1 (HECTD1, KIAA1131)
Function:
1) probable E3 ubiquitin-protein ligase ubiquitin conjugation, 3rd step
2) may be required for development of the head mesenchyme & neural tube closure
3) interacts with IGSF1
Structure:
- belongs to the UPL family, K-HECT subfamily
- contains 4 ANK repeats
- contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
- contains 1 MIB/HERC2 domain
General
ankyrin repeat domain protein (ANKRD)
phosphoprotein
E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein
Properties
SIZE: entity length = 2610 aa
MW = 289 kD
COMPARTMENT: cytoplasm
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 395-424
ankyrin repeat
NAME: ankyrin repeat
SITE: 426-455
ankyrin repeat
NAME: ankyrin repeat
SITE: 459-491
ankyrin repeat
NAME: ankyrin repeat
SITE: 579-612
Ser phosphorylation site {S632}
C2 domain {1266-1338}
MOTIF: binding site
FOR-BINDING-OF: phospholipid
Ca+2-binding site
serine-rich region {1350-1649}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S1390}
Ser phosphorylation site {S1488}
Ser phosphorylation site {S1772}
K-box {2029-2103}
HECT domain {2151-2610}
MOTIF: cysteine residue {C2579}
Database Correlations
UniProt Q9ULT8
PFAM correlations
Entrez Gene 25831
Kegg hsa:25831
References
UniProt :accession Q9ULT8