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ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1)
Function:
- may specifically dephosphorylate Ser-5 of heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit
phosphoprotein + H2O protein + phosphate
Cofactor: Mg+2
Kinetic parameters:
- Optimum pH is 5.0
Structure:
- contains 1 FCP1 homology domain
- contains 1 ubiquitin-like domain
Compartment: nucleus
Expression:
- broadly expressed
- highest levels in placenta, lung, testis, ovary
Pathology:
- up-regulated in tumor tissues
General
nuclear protein
phosphoprotein phosphatase
Properties
SIZE: MW = 37 kD
entity length = 318 aa
COMPARTMENT: cell nucleus
MOTIF: Ubiquitin-like {3-81}
FCP1 homology {133-294}
STATE: active state
Database Correlations
UniProt Q8WVY7
PFAM correlations
ENZYME 3.1.3.16
References
UniProt :accession Q8WVY7