SUMO-activating enzyme subunit 1; ubiquitin-like 1-activating enzyme E1A (SAE1, AOS1, SUA1, UBLE1A)

Function: - heterodimer of SAE1 & UBA2/SAE2 acts as a E1 ligase for SUMO1, SUMO2, SUMO3, & probably SUMO4 - enzyme regulatory subunit - mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein & a conserved active site Cys on UBA2/SAE2 - protein modification; protein sumoylation - phosphorylated upon DNA damage, probably by ATM or ATR - heterodimer of SAE1 & UBA2/SAE2 corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1 - interacts with UBE2I Structure: belongs to the ubiquitin-activating E1 family Compartment: nucleus Expression: - expression increases during S phase & drops in G2 phase (at protein level) Laboratory: - SUMO-activating enzyme subunit 1 Ab in serum - SUMO-activating enzyme subunit 1 IgG in serum

General

enzyme regulatory subunit nuclear protein phosphoprotein

Properties

SIZE: entity length = 346 aa MW = 38 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S185}

Database Correlations

OMIM 613294 UniProt Q9UBE0 Pfam PF00899 Entrez Gene 10055 Kegg hsa:10055

References

UniProt :accession Q9UBE0