E3 ubiquitin-protein ligase RING2; Huntingtin-interacting protein 2-interacting protein 3; HIP2-interacting protein 3; protein DinG; RING finger protein 1B; RING1b; RING finger protein 2; RING finger protein BAP-1 (RNF2, BAP1, DING, HIPI3, RING1B)

Function: 1) E3 ubiquitin ligase protein, ubiquitin conjugation, 3rd step 2) mediates monoubiquitination of Lys-119 of histone H2A 3) X chromosome inactivation of female mammals 4) initiation of both imprinted & random X inactivation 5) component of Polycomb group multiprotein PRC1 complex 6) component of: PCR1 complex, E2F6.com-1 complex 7) interacts with RYBP, HIP2, TFCP2. 8) association to chromosomal DNA is cell-cycle dependent Structure: contains 1 RING-type Zn⁺² finger Compartment: - nucleus - enriched on inactive X chromosome

General

nuclear protein phosphoprotein ring finger protein E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein

Properties

SIZE: entity length = 336 aa MW = 38 kD COMPARTMENT: cell nucleus MOTIF: HIP2 interaction {1-179} MOTIF: RING-finger {51-91} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif Ser phosphorylation site {S168} Ser phosphorylation site {S203}

Database Correlations

OMIM 608985 UniProt Q99496 Pfam PF00097 Entrez Gene 6045 Kegg hsa:6045

References

UniProt :accession Q99496