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probable E3 ubiquitin-protein ligase MYCBP2; Myc-binding protein 2; Pam/highwire/rpm-1 protein; protein associated with Myc (MYCBP2, KIAA0916, PAM)
Function:
1) E3 ubiquitin ligase, ubiquitin conjugation, 3rd step
2) mediates ubiquitination & proteasomal degradation
3) regulation of transcriptional activation by MYC
4) synaptogenesis
5) interactions: MYC, TSC2 (tuberin)/TSC1 (hamartin) complex
Structure:
- belongs to the highwire family
- contains 1 B box-type Zn+2 finger
- contains 1 DOC domain
- contains 1 filamin repeat
- contains 5 RCC1 repeats
- contains 1 RING-type Zn+2 finger
Compartment:
- nucleus
- colocalizes with TSC1 & TSC2 along neurites & growth cones
Alternative splicing: named isoforms=2
Expression:
- expressed in all tissues
- especially abundant in brain & thymus
General
nuclear protein
phosphoprotein
ring finger protein
E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein
Properties
SIZE: entity length = 4640 aa
MW = 510 kD
COMPARTMENT: cell nucleus
MOTIF: lysine-rich region {65-88}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S140}
Ser phosphorylation site {S143}
Ser phosphorylation site {S145}
RCC1 repeat {562-617}
RCC1 repeat {661-717}
cysteine-rich region {728-776}
RCC1 repeat {869-919}
RCC1 repeat {920-970}
RCC1 repeat {972-1028}
Ser phosphorylation site {S1586}
filamin repeat {2303-2405}
Thr phosphorylation site {T2645}
serine-rich region {2682-2806}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S2749}
Ser phosphorylation site {S2751}
Ser phosphorylation site {S2774}
Ser phosphorylation site {S2831}
Ser phosphorylation site {S2882}
Ser phosphorylation site {S3052}
lysine-rich region {3156-3177}
MOTIF: lysine residue (SEVERAL)
glycine-rich region {3224-3255}
Ser phosphorylation site {S3422}
Ser phosphorylation site {S3440}
Ser phosphorylation site {S3467}
DOC {3681-3859}
MOTIF: Ser phosphorylation site {S3758}
Thr phosphorylation site {T3883}
Ser phosphorylation site {S3893}
Ser phosphorylation site {S3894}
RING-finger {4390-4441}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
zinc finger B box
SITE: 4544-4594
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 610392
UniProt O75592
PFAM correlations
Entrez Gene 23077
Kegg hsa:23077
References
UniProt O75592