ubiquitin ligase protein MIB1; mind bomb homolog 1; DAPK-interacting protein 1; DIP-1; zinc finger ZZ type with ankyrin repeat domain protein 2 (MIB1, DIP1, KIAA1323, ZZANK2)

Function: 1) mediates ubiquitination of delta proteins 2) regulates delta1-mediated Notch signaling by ubiquitinating the intracellular domain of delta1, leading endocytosis 3) mediates ubiquitination & subsequent proteasomal degradation of DAPK1 a) antagonizes anti-apoptotic effects of DAPK1 b) promotes TNF-induced apoptosis 4) ubiquitin conjugation, 3rd step Compartment: cytoplasm, localizes to the plasma membrane Expression: - widely expressed at low level - ubiquitinated Pathology: - in epilepsy brain tissue, levels of expression are increased in cytoplasm & endoplasmic reticulum

General

ankyrin repeat domain protein (ANKRD) E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein

Properties

SIZE: MW = 110 kD entity length = 1006 aa COMPARTMENT: mitochondria cytoplasm MOTIF: C2 domain {15-74} MOTIF: binding site FOR-BINDING-OF: phospholipid Ca+2-binding site Zinc finger NAME: Zinc finger SITE: 79-126 EFFECTOR-BOUND: Zn+2 C2 domain {154-221} MOTIF: binding site FOR-BINDING-OF: phospholipid Ca+2-binding site ankyrin repeat NAME: ankyrin repeat (9) SITE: 430-729 RING-finger {819-854} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif RING-finger {866-901} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif coiled coil {935-962} RING-finger {963-996} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif

Database Correlations

OMIM 608677 UniProt Q86YT6 PFAM correlations ENZYME 6.3.2.19

References

UniProt :accession Q86YT6