ubiquitin-conjugating enzyme E2 variant 1; UEV-1; CROC-1; TRAF6-regulated IKK activator 1 beta Uev1A (UBE2V1, CROC1, UBE2V, UEV1 P/OKcl19)

Function: - has no ubiquitin ligase activity on its own - the UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63 - this type of poly-ubiquitination activates IKK & does not seem to involve protein degradation by the proteasome - role in activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 & TRAF2 - mediates transcriptional activation of target genes - role in cell cycle progression & differentiation - role in error-free DNA repair - contributes to survival of cells after DNA damage - heterodimer with UBE2N - UBE2V2-UBE2N heterodimer interacts with E3 ligase STUB1 (via the U-box domain) - complex has a specific Lys-63-linked polyubiquitination activity - interacts with TRAF6 Structure: - belongs to the ubiquitin-conjugating enzyme family Compartment: - nucleus - excluded from the nucleolus Alternative splicing: - named isoforms=5 - additional isoforms seem to exist Expression: - highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow & pancreas - expressed at low levels in heart, breast, placenta, brain, liver, kidney, stomach & lung - down-regulated during differentiation of cultured colorectal adenocarcinoma cells Notes: - in humans, TMEM189/KUA & UBE2V1/UEV1 are adjacent genes which can produce independent proteins & can also be fused to form a TMEM189-UBE2V1 hybrid protein

General

nuclear protein phosphoprotein ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Properties

SIZE: entity length = 147 aa MW = 16 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S146}

Database Correlations

OMIM 602995 UniProt Q13404 Pfam PF00179 LOCUS-LINK correlations KEGG correlations

References

UniProt :accession Q13404