ubiquitin-conjugating enzyme E2 E1; UbcH6; ubiquitin carrier protein E1; ubiquitin-protein ligase E1 (UBE2E1, UBCH6)

Function: - accepts ubiquitin from the E1 complex & catalyzes its covalent attachment to other proteins - catalyzes covalent attachment of ISG15 to other proteins - mediates selective degradation of short-lived & abnormal proteins - in vitro catalyzes Lys-48-linked polyubiquitination - protein modification; protein ubiquitination - ISGylation suppresses ubiquitin E2 enzyme activity - interacts with RNF14 Structure: - belongs to the ubiquitin-conjugating enzyme family Compartment: nucleus

General

nuclear protein phosphoprotein ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Properties

SIZE: entity length = 193 aa MW = 21 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S2} serine-rich region {9-18} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S9} Ser phosphorylation site {S12} Tyr phosphorylation site {Y77} cysteine residue {C131}

Database Correlations

OMIM 602916 UniProt P51965 Pfam PF00179 Entrez Gene 7324 Kegg hsa:7324 ENZYME 6.3.2.19

References

UniProt :accession P51965