ubiquitin-conjugating enzyme E2 E3; UbcH9; ubiquitin carrier protein E3; ubiquitin-conjugating enzyme E2-23 kD; ubiquitin-protein ligase E3 (UBE2E3, UBCE4, UBCH9)

Function: - accepts ubiquitin from the E1 complex & catalyzes its covalent attachment to other proteins - in vitro catalyzes Lys-11- & Lys-48-, as well as Lys-63-linked polyubiquitination - participates in regulation of transepithelial Na⁺ transport in renal cells - may be involved in cell growth arrest - protein modification; protein ubiquitination - the ubiquitin-loaded form interacts specifically with importin-11 (IPO11), leading to its import into the nucleus - interacts with NEDD4L Structure: - belongs to the ubiquitin-conjugating enzyme family Compartment: - nucleus, cytoplasm - shuttles between the nucleus & cytoplasm (IPO11-dependent) Expression: - ubiquitously expressed at low levels - highly expressed in skeletal muscle

General

nuclear protein phosphoprotein ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Properties

SIZE: entity length = 207 aa MW = 23 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: Ser phosphorylation site {S3} Ser phosphorylation site {S12} Tyr phosphorylation site {Y91} cysteine residue {C145}

Database Correlations

OMIM 604151 UniProt Q969T4 Pfam PF00179 Entrez Gene 10477 Kegg hsa:10477 ENZYME 6.3.2.19

References

UniProt :accession Q969T4