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ubiquitin carboxyl-terminal hydrolase 36; deubiquitinating enzyme 36; ubiquitin thiolesterase 36; ubiquitin-specific-processing protease 36 (USP36, KIAA1453)
Function:
- may be required for maintaining multiple types of adult stem cells
- may function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thus preventing histone H3 Lys-4 trimethylation
- thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
- interacts with PAF1 (putative)
Structure: belongs to the peptidase C19 family
Compartment: nucleus, nucleolus
Alternative splicing: named isoforms=2
Expression: broadly expressed
General
nuclear protein
phosphoprotein
ubiquitin C-terminal hydrolase; UCH; ubiquitin thiolesterase; ubiquitin-specific processing protease; deubiquitinating enzyme
Properties
SIZE: entity length = 1121 aa
MW = 123 kD
COMPARTMENT: cell nucleus
MOTIF: cysteine residue {C131}
histidine residue {H382}
Ser phosphorylation site {S464}
Ser phosphorylation site {S494}
Ser phosphorylation site {S513}
Ser phosphorylation site {S515}
Ser phosphorylation site {S546}
Ser phosphorylation site {S582}
Ser phosphorylation site {S613}
Ser phosphorylation site {S614}
Thr phosphorylation site {T653}
Ser phosphorylation site {S667}
Thr phosphorylation site {T680}
Ser phosphorylation site {S682}
Ser phosphorylation site {S713}
Ser phosphorylation site {S742}
Tyr phosphorylation site {Y874}
Ser phosphorylation site {S952}
Ser phosphorylation site {S1048}
Database Correlations
OMIM 612543
UniProt Q9P275
Pfam PF00443
Entrez Gene 57602
Kegg hsa:57602
ENZYME 3.4.19.12
References
UniProt :accession Q9P275