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ubiquitin carboxyl-terminal hydrolase 26; deubiquitinating enzyme 26; ubiquitin thiolesterase 26; ubiquitin-specific-processing protease 26 (USP26)
Function:
- role in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (putative)
- deubiquinates the androgen receptor & regulates the androgen receptor signaling pathway
- thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
- interacts with AR
Structure: belongs to the peptidase C19 family
Compartment: nucleus
Related
ubiquitin (UBCEP2, UBB, UBC)
General
nuclear protein
ubiquitin C-terminal hydrolase; UCH; ubiquitin thiolesterase; ubiquitin-specific processing protease; deubiquitinating enzyme
Properties
SIZE: entity length = 913 aa
MW = 104 kD
COMPARTMENT: cell nucleus
MOTIF: cysteine residue {C304}
histidine residue {H841}
Database Correlations
OMIM 300309
UniProt Q9BXU7
Pfam PF00443
Entrez Gene 83844
Kegg hsa:83844
ENZYME 3.4.19.12
References
- UniProt :accession Q9BXU7
- OMIM :accession 300309