ubiquitin carboxyl-terminal hydrolase 22; deubiquitinating enzyme 22; ubiquitin thiolesterase 22; ubiquitin-specific-processing protease 22 (USP22, KIAA1063)

Function: - histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA - catalyzes deubiquitination of both histones H2A & H2B, thereby acting as a coactivator - recruited to specific gene promoters by activators such as MYC, where it is required for transcription - required for nuclear receptor-mediated transactivation & cell cycle progression - thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin - component of SAGA transcription coactivator-HAT complex - within the SAGA complex, ATXN7L3, ENY2 & USP22 form a subcomplex required for histone deubiquitinylation - interacts directly with ATXN7L3; leading to its recruitment to the SAGA complex Structure: - belongs to the peptidase C19 family, UBP8 subfamily - contains 1 UBP-type Zn⁺² finger Compartment: nucleus (probable) Alternative splicing: named isoforms=2 Expression: - moderately expressed in heart & skeletal muscle, - weakly expressed in lung & liver

General

nuclear protein ubiquitin C-terminal hydrolase; UCH; ubiquitin thiolesterase; ubiquitin-specific processing protease; deubiquitinating enzyme zinc finger protein

Properties

SIZE: entity length = 525 aa MW = 60 kD COMPARTMENT: cell nucleus MOTIF: Zinc finger NAME: Zinc finger SITE: 61-121 EFFECTOR-BOUND: Zn+2 cysteine residue {C185} histidine residue {H479}

Database Correlations

UniProt Q9UPT9 PFAM correlations Entrez Gene 23326 Kegg hsa:23326 ENZYME 3.4.19.12

References

UniProt :accession Q9UPT9