ubiquitin carboxyl-terminal hydrolase 21; deubiquitinating enzyme 21; ubiquitin thiolesterase 21; ubiquitin-specific-processing protease 21 (USP21, PP1490)

Function: - deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator - deubiquitination of histone H2A releaves the repression of di- & trimethylation of histone H3 at Lys-4, resulting in regulation of transcriptional initiation - regulates gene expression via histone H2A deubiquitination (putative) - also capable of removing NEDD8 from NEDD8 conjugates but has no effect on sentrin-1 conjugates - thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin Structure: - belongs to the peptidase C19 family, USP21 subfamily Compartment: nucleus (putative) Alternative splicing: named isoforms=3 Expression: - highly expressed in heart, pancreas & skeletal muscle - also expressed in brain, placenta, liver & kidney - expressed at very low level in lung

General

nuclear protein ubiquitin C-terminal hydrolase; UCH; ubiquitin thiolesterase; ubiquitin-specific processing protease; deubiquitinating enzyme

Properties

SIZE: entity length = 565 aa MW = 63 kD COMPARTMENT: cell nucleus MOTIF: cysteine residue {C221} Zn+2-binding site SITE: 384-384 Zn+2-binding site SITE: 387-387 Zn+2-binding site SITE: 437-437 Zn+2-binding site SITE: 440-440 histidine residue {H518}

Database Correlations

OMIM 604729 UniProt Q9UK80 Pfam PF00443 Entrez Gene 27005 Kegg hsa:27005 ENZYME 3.4.19.12

References

UniProt :accession Q9UK80