ubiquitin carboxyl-terminal hydrolase 17-like protein 6 (ubiquitin thioesterase 17-like protein 6, ubiquitin-specific-processing protease 17-like protein 6, deubiquitinating enzyme 17-like protein 6, USP17L6, USP17C, USP17D, USP17N)

Function: - seems to be non-functional in the regulation of apoptosis - cleaves ubiquitin fusion protein substrates ubiquitin C-terminal thioester + H₂O ubiquitin + a thiol Structure: belongs to the peptidase C19 family, USP17 subfamily Compartment: nucleus, cytoplasm Note: - the RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17 - it is present with an interindividual variation in copy number & between 20 to 103 copies can be found in the genome both on chromosome 4 & chromosome 8

General

nuclear protein ubiquitin C-terminal hydrolase; UCH; ubiquitin thiolesterase; ubiquitin-specific processing protease; deubiquitinating enzyme

Properties

SIZE: entity length = 398 aa MW = 45 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: cysteine residue {C89} histidine residue {H325} histidine residue {H334}

Database Correlations

UniProt Q6QN14 Pfam PF00443 ENZYME 3.1.2.15

References

UniProt :accession Q6QN14