ubiquitin carboxyl-terminal hydrolase 17-like protein 2 (ubiquitin thioesterase 17-like protein 2, ubiquitin-specific-processing protease 17-like protein 2, deubiquitinating enzyme 17-like protein 2, deubiquitinating protein 3, DUB-3, USP17L2, DUB3)

Function: - role in cell apoptosis - cleaves ubiquitin fusion protein substrates ubiquitin C-terminal thioester + H₂O ubiquitin + a thiol Structure: belongs to the peptidase C19 family, USP17 subfamily Compartment: nucleus (putative) Expression: - broadly expressed - up-regulated by interleukin-4 & interleukin-6 Note: - the RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17 - it is present with an interindividual variation in copy number & between 20 to 103 copies can be found in the genome both on chromosome 4 & chromosome 8

General

nuclear protein ubiquitin C-terminal hydrolase; UCH; ubiquitin thiolesterase; ubiquitin-specific processing protease; deubiquitinating enzyme

Properties

SIZE: entity length = 530 aa MW = 60 kD COMPARTMENT: cell nucleus MOTIF: cysteine residue {C89} histidine residue {H325} histidine residue {H334}

Database Correlations

UniProt Q6R6M4 Pfam PF00443 KEGG correlations ENZYME 3.1.2.15

References

UniProt :accession Q6R6M4