ubiquitin carboxyl-terminal hydrolase 17-like protein 12 (USP17L12)

Function: - deubiquitinating enzyme - removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, & the cellular response to viral infection (putative) - thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin Structure: - belongs to the peptidase C19 family, USP17 subfamily Compartment: - nucleus (putative) - endoplasmic reticulum (putative) Genetics: - the RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene - it is present with an interindividual variation in copy number, ranging from 20-103, & can be found in the genome on chromosome 4 & chromosome 8 - the high similarity between the UPS17-like genes makes it difficult to specifically assign data to a particular gene of the family, oligonucleotides designed in RNAi experiments are for instance not specific for a given UPS17-like gene

General

nuclear protein ubiquitin C-terminal hydrolase; UCH; ubiquitin thiolesterase; ubiquitin-specific processing protease; deubiquitinating enzyme

Properties

SIZE: entity length = 530 aa MW = 60 kD COMPARTMENT: cell nucleus MOTIF: cysteine residue {C89} histidine residue {H334}

Database Correlations

UniProt C9JPN9 PFAM correlations Entrez Gene 100287 Kegg hsa:100287 ENZYME 3.4.19.12

References

UniProt :accession C9JPN9