ubiquitin carboxyl-terminal hydrolase 17; ubiquitin thioesterase 17; ubiquitin-specific-processing protease 17; deubiquitinating enzyme 17; ubiquitin carboxyl-terminal hydrolase 17-like protein 24 (USP17, USP17L24, USP17H, USP17I, USP17J, USP17K, USP17M, USP17L25, USP17L26, USP17L27, USP17L28, USP17L29, USP17L30)

Function: - deubiquitinating enzyme - removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include: - cell proliferation - progression through the cell cycle - apoptosis - cell migration - cellular response to viral infection - thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin Structure: - belongs to the peptidase C19 family, USP17 subfamily Compartment: - nucleus, nucleolus, endoplasmic reticulum Expression: - expressed in heart, brain, liver & skeletal muscle Genetics: - the RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17 - it is present with an interindividual variation in copy number & between 20 to 103 copies - can be found both on chromosome 4 & chromosome 8

General

nuclear protein ubiquitin C-terminal hydrolase; UCH; ubiquitin thiolesterase; ubiquitin-specific processing protease; deubiquitinating enzyme

Properties

SIZE: entity length = 530 aa MW = 60 kD COMPARTMENT: cell nucleus endoplasmic reticulum MOTIF: cysteine residue {C89} histidine residue {H334}

Database Correlations

OMIM 607011 UniProt Q0WX57 PFAM correlations LOCUS-LINK correlations KEGG correlations ENZYME 3.1.2.15

References

UniProt :accession Q0WX57