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ubiquitin carboxyl-terminal hydrolase 11; deubiquitinating enzyme 11; ubiquitin thiolesterase 11; ubiquitin-specific-processing protease 11 (USP11, UHX1)
Function:
- protease that can remove conjugated ubiquitin from target proteins & polyubiquitin chains
- inhibits degradation of target proteins by the proteasome
- plays a role in the regulation of pathways leading to NF-kappa-B activation
- plays a role in the regulation of DNA repair after double-stranded DNA breaks
- thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
- interacts with RANBP9/RANBPM. interacts with BRCA2, CHUK/IKKA & NFKBIA
- interacts with papilloma virus protein 16E7
Structure:
- belongs to the peptidase C19 family
- contains 1 DUSP domain
Compartment:
- nucleus, cytoplasm
- predominantly nuclear
- associates with chromatin
Note:
- it is uncertain whether Met-1 or Met-44 is the initiator
Related
ubiquitin (UBCEP2, UBB, UBC)
General
nuclear protein
phosphoprotein
ubiquitin C-terminal hydrolase; UCH; ubiquitin thiolesterase; ubiquitin-specific processing protease; deubiquitinating enzyme
Properties
SIZE: entity length = 963 aa
MW = 110 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: DUSP {76-184}
cysteine residue {C318}
histidine residue {H888}
Ser phosphorylation site {S948}
Ser phosphorylation site {S953}
Database Correlations
OMIM 300050
UniProt P51784
PFAM correlations
Entrez Gene 8237
Kegg hsa:8237
ENZYME 3.4.19.12
References
- UniProt :accession P51784
- OMIM :accession 300050