U6 snRNA-associated Sm-like protein LSm1; cancer-associated Sm-like; small nuclear ribonuclear CaSm (LSM1, CASM)

Function: - plays a role in replication-dependent histone mRNA degradation - binds specifically to the 3'-terminal U-tract of U6 snRNA - interacts with SLBP - interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase - LSm subunits form a heteromer with a donut shape Structure: belongs to the snRNP Sm proteins family Compartment: nucleus (putative) Pathology: - elevated expression in pancreatic cancer & in several cancer-derived cell lines

Properties

SIZE: entity length = 133 aa MW = 15 kD COMPARTMENT: cell nucleus MOTIF: RNA-binding motif FOR-BINDING-OF: ribonucleic acid

Database Correlations

OMIM 607281 UniProt O15116 Pfam PF01423 Entrez Gene 27257 Kegg hsa:27257

References

UniProt :accession O15116