Search
U4/U6 small nuclear ribonucleoprotein Prp31 (pre-mRNA splicing factor 31, U4/U6 snRNP 61 kD protein, hPrp31, serologically defined breast cancer antigen NY-BR-99, PRPF31, PRP31)
Function:
1) pre-mRNA splicing, required for U4/U6.U5 tri-snRNP formation
2) part of a tri-snRNP complex
3) interacts with C20orf14/U5 snRNP-associated 102 kD protein
Compartment:
- nucleus, nuclear speckle, nucleus, Cajal body
- predominantly found in speckles & in Cajal bodies
Alternative splicing: named isoforms=3
Expression: ubiquitously expressed
Pathology:
- defects in PRPF31 are the cause of retinitis pigmentosa 11
Related
retinitis pigmentosa type 11 (RP11)
General
nuclear protein
ribonucleoprotein
Properties
SIZE: MW = 55 kD
entity length = 499 aa
COMPARTMENT: cell nucleus
MOTIF: glutamate-rich region {16-19}
MOTIF: glutamate residue (SEVERAL)
glutamate-rich region {25-29}
MOTIF: glutamate residue (SEVERAL)
NOP {186-334}
Database Correlations
OMIM correlations
MORBIDMAP 606419
UniProt Q8WWY3
PFAM correlations
References
UniProt :accession Q8WWY3