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U1 70 kD protein (SNRNP70)
Function: phosphorylation inhibits splicing activity
Related
U1 RNP 70 kD Ab in serum
General
nuclear protein
protein subunit
RNA-binding protein
Properties
SIZE: MW = 70 kD
MOTIF: RNP motif
NAME: RNP motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
Ser phosphorylation site
Database Correlations
OMIM 180740
UniProt P08621
References
- Nagai K, Oubridge C, Jessen TH, Li J, Evans PR.
Crystal structure of the RNA-binding domain of the U1 small
nuclear ribonucleoprotein A.
Nature. 1990 Dec 6;348(6301):515-20.
PMID: 2147232
- Tazi J et al
Thiophosphorylation of U1-70K protein inhibits pre-mRNA
splicing.
Nature. 1993 May 20;363(6426):283-6.
PMID: 8387646
Component-of
U1-snRNP; U1 small nuclear ribonucleoprotein