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T-cell surface protein tactile; T cell-activated increased late expression protein; cell surface antigen CD96 (CD96)
Function:
- may play role in adhesive interactions of activated T cells & NK cells during the late phase of the immune response promotes NK cell-target adhesion by interacting with PVR present on target cells
- may function at a time after T & NK cells have penetrated the endothelium using integrins & selectins, when they are actively engaging diseased cells & moving within areas of inflammation
- interacts with PVR
Structure:
- homodimer; disulfide-linked.
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 2 Ig-like V-type domain (immunoglobulin-like)
Compartment: membrane; single-pass type 1 membrane protein
Alternative splicing: named isoforms=2
Expression:
- expressed on normal T-cell lines & clones, & some transformed T-cells, but no other cultured cell lines tested
- expressed at very low levels on activated B-cells
- expressed at low levels on peripheral T-cells & is strongly up-regulated after activation, peaking 6 to 9 days after the activating stimulus
Pathology:
- chromosomal translocation t(3;18)(q13.13;q12.1) involving CD96 is associated with C syndrome
- defects in CD96 are a cause of C-like syndrome
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
Properties
SIZE: entity length = 585 aa
MW = 66 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {38-125}
MOTIF: N-glycosylation site {N42}
cysteine residue {C45}
MODIFICATION: cysteine residue {C118}
N-glycosylation site {N97}
N-glycosylation site {N107}
cysteine residue {C118}
MODIFICATION: cysteine residue {C45}
N-glycosylation site {N148}
immunoglobulin superfamily domain {156-238}
MOTIF: N-glycosylation site {N156}
cysteine residue {C163}
MODIFICATION: cysteine residue {C247}
N-glycosylation site {N166}
N-glycosylation site {N200}
N-glycosylation site {N215}
cysteine residue {C247}
MODIFICATION: cysteine residue {C163}
immunoglobulin superfamily domain {269-375}
MOTIF: N-glycosylation site {N277}
N-glycosylation site {N278}
cysteine residue {C290}
MODIFICATION: cysteine residue {C355}
N-glycosylation site {N300}
N-glycosylation site {N350}
cysteine residue {C355}
MODIFICATION: cysteine residue {C290}
N-glycosylation site {N368}
threonine-rich region {370-502}
MOTIF: threonine residue (SEVERAL)
N-glycosylation site {N435}
N-glycosylation site {N497}
transmembrane domain {520-540}
proline-rich region
SITE: 554-563
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM correlations
MORBIDMAP 606037
UniProt P40200
Entrez Gene 10225
Kegg hsa:10225
References
- UniProt :accession P40200
- Entrez Gene :accession 10225
- http://www.pathologyoutlines.com/cdmarkers.html
11 June 2005