T-cell surface glycoprotein CD8 beta-2 chain selections

T-cell surface glycoprotein CD8 beta-2 chain (CD8b pseudogene, CD8BP, CD8B2)

Function: - subunit of CD8 - identifies cytotoxic/suppressor T-cells that interact with MHC class 1 bearing targets - CD8 is thought to play a role in the process of T-cell mediated killing (putative) Structure: - contains 1 Ig-like V-type domain (immunoglobulin-like) - subunit of CD8, a heterodimer of an alpha & a beta chain linked by two disulfide bonds Compartment: cell membrane; (putative) Note: - could be the product of a pseudogene - gene appears functional but all the mRNAs identified are derived from CD8B/CD8B1 [2]

General

glycoprotein membrane protein

Properties

SIZE: entity length = 211 aa MW = 24 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-18} immunoglobulin superfamily domain {19-132} MOTIF: cysteine residue {C41} MODIFICATION: cysteine residue {C116} N-glycosylation site {N102} cysteine residue {C116} MODIFICATION: cysteine residue {C41} transmembrane domain {172-192}

Database Correlations

UniProt A6NJW9 Pfam PF07686

References

UniProt :accession A6NJW9
Nakayama K et al Recent duplication of the two human CD8 beta-chain genes. J Immunol. 1992 Mar 15;148(6):1919-27. PMID: 1541829

Component-of

CD8