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T cell receptor
Associates with CD3 in TcR/CD3 complex; in < 10% of T-cells, the TCR is formed by TCR-delta/TCR-gamma heterodimer. It is also associated with at least 2 src family tyrosine kinases, p59fyn & ZAP-70 [3]
Interactions
molecular events
Related
pre-T-cell receptor complex
proto-oncogene tyrosine-protein kinase Fyn; p59-Fyn; protooncogene syn; SLK (FYN)
T cell receptor delta (TCRD, TRD)
T cell receptor gamma; TCR-gamma (TCRG TRGC2)
T lymphocyte (T-cell, thymocyte)
T-cell receptor/CD3 complex
TCR alpha beta Ag in tissue
TCR alpha beta cells in blood
TCR gamma delta Ag in tissue
TCR gamma delta cells in blood
Zap-70 tyrosine kinase; zeta-associated protein 70 kD; Syk-related tyrosine kinase (ZAP70, SRK)
General
cell surface receptor
multisubunit protein
Figures/Diagrams
Figures/diagrams/slides/tables related to T cell receptor
Properties
COMPARTMENT: plasma membrane
CELL: T-cell
MOTIF: ligand-binding site
allosteric site
SUBUNITS: T cell receptor alpha
MOTIF: variable region
immunoglobulin superfamily domain
MOTIF: cysteine residue {C49}
MODIFICATION: cysteine residue {C116}
N-glycosylation site {N93}
cysteine residue {C116}
MODIFICATION: cysteine residue {C49}
membrane region
T cell receptor beta
MOTIF: N-glycosylation site (2)
variable region
immunoglobulin superfamily domain
membrane region
T cell receptor signalling subunit
MOTIF: transmembrane domain
Tyr phosphorylation site
References
- Springer TA.
Adhesion receptors of the immune system.
Nature. 1990 Aug 2;346(6283):425-34. Review.
PMID: 1974032
- Altman A, Coggeshall KM, Mustelin T.
Molecular events mediating T cell activation.
Adv Immunol. 1990;48:227-360. Review.
PMID: 1693465
- Migita K, Eguchi K, Kawabe Y, Nagataki S.
Tyrosine phosphorylation participates in peripheral T-cell
activation and programmed cell death in vivo.
Immunology. 1995 Aug;85(4):550-5.
PMID: 7558148
Component-of
T-cell receptor/CD3 complex
Components
T cell receptor alpha
T cell receptor beta
T cell receptor signalling subunit