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T-lymphoma invasion & metastasis-inducing protein 1; TIAM-1 (TIAM1)
Function:
- modulates the activity of RHO-like proteins & connects extracellular signals to cytoskeletal activities
- acts as a GDP-dissociation stimulator protein
a) stimulates the GDP-GTP exchange activity of RHO-like GTPases & activates them
b) activates RAC1, CDC42, & to a lesser extent, RHOA
- interacts with BAIAP2
Structure:
- belongs to the TIAM family
- contains 1 DH (DBL-homology) domain
- contains 1 PDZ domain (DHR domain)
- contains 2 PH domains
- contains 1 RBD (Ras-binding) domain
Expression:
- found in virtually all analyzed tumor cell lines including B-cell lymphomas & T-cells lymphomas, neuroblastomas, melanomas & carcinomas
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
myristoylated protein
phosphoprotein
Properties
SIZE: entity length = 1591 aa
MW = 178 kD
COMPARTMENT: cellular membrane
MOTIF: myristoylation site
SITE: G2
EFFECTOR-BOUND: myristate
Ser phosphorylation site {S231}
Ser phosphorylation site {S356}
Ser phosphorylation site {S358}
PH domain {434-549}
lysine-rich region {595-598}
MOTIF: lysine residue (SEVERAL)
RBD {765-832}
PDZ domain
NAME: PDZ domain
SITE: 845-908
Dbl homology domain {1040-1234}
PH domain {1261-1397}
MOTIF: Tyr phosphorylation site {Y1323}
arginine-rich region {1445-1449}
MOTIF: arginine residue (SEVERAL)
Database Correlations
OMIM 600687
UniProt Q13009
PFAM correlations
Entrez Gene 7074
Kegg hsa:7074
References
- UniProt :accession Q13009
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/TIAM1ID42557ch21q22.html