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T-cell factor 1; T-cell-specific transcription factor-1; transcription factor 7; TCF1-alpha; TCF-1 (TCF1, TCF7)

Function: - transcriptional activator involved in T-cell lymphocyte differentiation - necessary for the survival of CD4(+) CD8(+) immature thymocytes deficiency blocks transition from CD8+ to CD8+/CD4+ T-cells - isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role - binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene - regulates activity of the T-cell Receptor-alpha gene enhancer - may also act as feedback transcriptional repressor of CTNNB1 & TCF7L2 target genes - TLE1, TLE2, TLE3 & TLE4 repress transactivation mediated by TCF7 & CTNNB1 - binds the armadillo repeat of CTNNB1 & forms a stable complex - interacts with AES, TLE1, TLE2, TLE3 & TLE4 Structure: - belongs to the TCF/LEF family - contains 1 HMG box DNA-binding domain - very limited homology to the ETS domain exists within the HMG box Compartment: nucleus Alternative splicing: - named isoforms=16 - additional isoforms seem to exist Alternative promoter: - 2 series of isoforms, L & S, are produced by use of alternative promoter usage Expression: - expression is complex & overlapping during embryogenesis, but is restricted largely to lymphocytes postnatally - expression largely restricted to the thymus - expressed predominantly in T-cells - induced following T-cell activation - also detected in proliferating intestinal epithelial cells & in basal epithelial cells of mammary gland epithelium - induced by TCF7L2 & CTNNB1

Related

T-cell factor 1-alpha gene

General

DNA-binding protein transcription factor (TF)

Properties

SIZE: entity length = 383 aa MW = 42 kD COMPARTMENT: cell nucleus MOTIF: binding site SITE: 1-58 FOR-BINDING-OF: beta catenin HMG box SITE: 268-336 nuclear translocation signal {343-347}

Database Correlations

OMIM 189908 UniProt P36402 PFAM correlations

References

  1. Verbeek S, Izon D, Hofhuis F, Robanus-Maandag E, te Riele H, van de Wetering M, Oosterwegel M, Wilson A, MacDonald HR, Clevers H. An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature. 1995 Mar 2;374(6517):70-4. PMID: 7870176
  2. Macleod K, Leprince D, Stehelin D. The ets gene family. Trends Biochem Sci. 1992 Jul;17(7):251-6. Review. PMID: 1502727
  3. UniProt :accession P36402